Adams David W, Errington Jeff
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.
Nat Rev Microbiol. 2009 Sep;7(9):642-53. doi: 10.1038/nrmicro2198.
Bacterial cell division is orchestrated by a tubulin homologue, FtsZ, which polymerizes to form a ring-like structure that is both a scaffold for the assembly of the bacterial cytokinetic machinery and, at least in part, a source of the energy for constriction. FtsZ assembly is tightly regulated, and a diverse repertoire of accessory proteins contributes to the formation of a functional division machine that is responsive to cell cycle status and environmental stress. In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly.
细菌细胞分裂由微管蛋白同源物FtsZ精心调控，FtsZ聚合形成环状结构，该结构既是细菌细胞分裂机制组装的支架，至少部分也是收缩能量的来源。FtsZ组装受到严格调控，多种辅助蛋白有助于形成一个功能性分裂机器，该机器对细胞周期状态和环境应激有反应。在本综述中，我们描述了这些蛋白与FtsZ的相互作用，并讨论了我们对Z环组装理解的最新进展。
