Tvarijonaviciute Asta, Eralp Oya, Kocaturk Meric, Yilmaz Zeki, Ceron Jose J
Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Murcia University, 30100 Murcia, Spain.
Vet Immunol Immunopathol. 2011 Mar 15;140(1-2):147-51. doi: 10.1016/j.vetimm.2010.11.011. Epub 2010 Nov 18.
The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r=0.31; p<0.05). Adiponectin had also a significant negative correlation with CRP (r=-0.39; p<0.05) and Hp (r=-0.27; p<0.05), whereas IGF-1 had significant negative correlation with CRP (r=-0.52; p<0.001). The results obtained in the present study indicate that adiponectin and IGF-1 behave as negative acute phase proteins after acute inflammatory stimulus in dogs.
本研究的目的是评估实验性诱导的急性炎症对犬血清脂联素和胰岛素样生长因子1（IGF-1）水平的影响，并将它们的变化与其他公认的急性期蛋白（APPs）如C反应蛋白（CRP）和触珠蛋白（Hp）进行比较。因此，在健康犬静脉注射大肠杆菌脂多糖（0.02 mg/kg）后，测量脂联素、IGF-1水平及APPs谱，并与注射生理盐水（0.2 mL/kg）的犬进行比较。犬体内脂联素和IGF-1对内毒素的反应均降低。脂联素与IGF-1之间存在显著正相关（r=0.31；p<0.05）。脂联素与CRP（r=-0.39；p<0.05）和Hp（r=-0.27；p<0.05）也存在显著负相关，而IGF-1与CRP存在显著负相关（r=-0.52；p<0.001）。本研究获得的结果表明，在犬受到急性炎症刺激后，脂联素和IGF-1表现为负急性期蛋白。
