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[人群中抗生素高暴露情况以及按性别和年龄的差异]

[High exposure to antibiotics in the population and differences by sex and age].

作者信息

Serna M Catalina, Ribes Esther, Real Jordi, Galván Leonardo, Gascó Eduardo, Godoy Pere

机构信息

Universidad de Lleida, España.

出版信息

Aten Primaria. 2011 May;43(5):236-44. doi: 10.1016/j.aprim.2010.04.015. Epub 2010 Dec 8.

DOI:10.1016/j.aprim.2010.04.015
PMID:21145134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7024977/
Abstract

PURPOSE

To determine antibiotic use and its distribution by age and gender, as well as the most prescribed therapeutic group.

DESIGN

Observational descriptive with retrospective data.

SETTINGS AND PARTICIPANTS

Population from the Lleida (Spain) Health Region receiving antibiotic prescriptions from 2002 to 2007.

MEASUREMENTS

Daily Dose Per Inhabitant (DID) was calculated, as well as the number of patients under treatment. The study variables were: age, gender, number of patients under antibiotic treatment and pharmacological group.

RESULTS

Mean prevalence of patients receiving antibiotics was 36.93% (33.51% in men and 40.42% in women). The DID in Lleida during 2007 is 23.52. The majority (56%) had received antibiotics once a year. The antibiotic consumption prevalence has a "V" shape with higher values among children and old people. There is an annual exposure to antibiotics in 58.8% of the 0 to 4 years-old age group. The most prescribed antibiotic is amoxicillin/clavulanic.

CONCLUSIONS

We observe a high antibiotic prescription rate among children and older people, the high consumption in childhood being of note. There is also a higher use of antibiotics among women and changing of prescription towards broad spectrum antibiotics.

摘要

目的

确定抗生素的使用情况及其按年龄和性别的分布,以及最常开具处方的治疗组。

设计

采用回顾性数据的观察性描述研究。

研究地点和参与者

来自西班牙莱里达卫生区2002年至2007年接受抗生素处方的人群。

测量指标

计算人均每日剂量(DID)以及接受治疗的患者数量。研究变量包括:年龄、性别、接受抗生素治疗的患者数量和药物组。

结果

接受抗生素治疗的患者平均患病率为36.93%(男性为33.51%,女性为40.42%)。2007年莱里达的人均每日剂量为23.52。大多数人(56%)每年接受一次抗生素治疗。抗生素消费患病率呈“V”形,儿童和老年人中的患病率较高。0至4岁年龄组中有58.8%的人每年接触抗生素。最常开具处方的抗生素是阿莫西林/克拉维酸。

结论

我们观察到儿童和老年人中抗生素处方率较高,儿童时期的高消费量值得关注。女性中抗生素的使用也较多,并且处方有向广谱抗生素转变的趋势。

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Pediatrics. 2009 Aug;124(2):439-45. doi: 10.1542/peds.2007-3736. Epub 2009 Jul 20.
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Ten years of antibiotic consumption in ambulatory care: trends in prescribing practice and antibiotic resistance in Austria.门诊医疗中十年的抗生素使用情况:奥地利的处方实践趋势及抗生素耐药性
BMC Infect Dis. 2009 May 13;9:61. doi: 10.1186/1471-2334-9-61.
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Antibiotic use and population ecology: how you can reduce your "resistance footprint".抗生素的使用与种群生态学:如何减少你的“耐药足迹”
CMAJ. 2009 Feb 17;180(4):416-21. doi: 10.1503/cmaj.080626.
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Antimicrobial drug use and resistance in Europe.欧洲抗菌药物的使用与耐药性
Emerg Infect Dis. 2008 Nov;14(11):1722-30. doi: 10.3201/eid1411.070467.
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European Surveillance of Antimicrobial Consumption (ESAC): quality indicators for outpatient antibiotic use in Europe.欧洲抗菌药物消费监测(ESAC):欧洲门诊抗生素使用的质量指标
Qual Saf Health Care. 2007 Dec;16(6):440-5. doi: 10.1136/qshc.2006.021121.
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Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries.2004年美国与27个欧洲国家门诊全身用抗菌药物使用情况比较。
Clin Infect Dis. 2007 Apr 15;44(8):1091-5. doi: 10.1086/512810. Epub 2007 Mar 2.
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