Malo Sara, Bjerrum Lars, Feja Cristina, Lallana María Jesús, Abad José María, Rabanaque-Hernández María José
Departamento de Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain.
Eur J Clin Pharmacol. 2014 Mar;70(3):347-53. doi: 10.1007/s00228-013-1619-0. Epub 2013 Dec 10.
The aim of the study was to analyse and compare the quality of outpatient antimicrobial prescribing in Denmark and Aragón (in northeastern Spain), with the objective of assessing inappropriate prescribing.
Outpatient antimicrobial prescription data were obtained from the National Institute for Health Data and Disease Control in Denmark, and from the Aragón Information System of Drug Consumption. The number of Defined Daily Doses (DDD) of the different substances were calculated, and the quality of the antimicrobial prescription was analysed using the 'Drug Utilization 90 %' method and the European Surveillance of Antimicrobial Consumption (ESAC) quality indicators for outpatient antimicrobial use.
The majority of the prescriptions (90 % of total DDD) were comprised of 14 (of 39) different antimicrobials in Denmark, based mainly on narrow spectrum penicillin, and 11 (of 59) antimicrobials in Aragón, principally broad spectrum penicillins. The quality indicators described an elevated consumption of antimicrobials and an important seasonal variation in Aragón. In Denmark, the values obtained reflected a more moderate use with minor seasonal variation.
The results showed important differences between the two study areas in relation to quantity and quality of outpatient antimicrobial prescription. The data indicate an overuse (and/or misuse) of antimicrobials in the Spanish region, despite national and local guidelines. The pattern of prescription in Denmark reflects a better adherence to recommendations.
本研究旨在分析和比较丹麦与阿拉贡（西班牙东北部）门诊抗菌药物处方的质量，以评估不适当处方情况。
门诊抗菌药物处方数据分别来自丹麦国家卫生数据与疾病控制研究所以及阿拉贡药物消费信息系统。计算不同药物的限定日剂量（DDD）数量，并采用“药物利用90%”方法以及欧洲门诊抗菌药物消费监测（ESAC）质量指标分析抗菌药物处方质量。
丹麦大部分处方（占总DDD的90%）由39种不同抗菌药物中的14种组成，主要为窄谱青霉素；阿拉贡的大部分处方（占总DDD的90%）由59种抗菌药物中的11种组成，主要为广谱青霉素。质量指标显示阿拉贡抗菌药物消费量较高且存在明显的季节性变化。在丹麦，所获得的数据反映出使用更为适度且季节性变化较小。
结果表明两个研究地区在门诊抗菌药物处方的数量和质量方面存在重要差异。数据表明，尽管有国家和地方指南，西班牙地区仍存在抗菌药物过度使用（和/或滥用）的情况。丹麦的处方模式反映出对建议的更好遵循。
