Asbestos Diseases Research Institute (ADRI), Bernie Banton Centre, University of Sydney, Concord, Australia.
Crit Rev Oncol Hematol. 2011 Nov;80(2):193-208. doi: 10.1016/j.critrevonc.2010.11.004. Epub 2010 Dec 8.
The control of gene expression by microRNAs influences many cellular processes and has been implicated in the control of many (patho)physiological states. Recently, microRNAs have been detected in serum and plasma, and circulating microRNA profiles have now been associated with a range of different tumour types, diseases such as stroke and heart disease, as well as altered physiological states such as pregnancy. Here we review the disease-specific profiles of circulating microRNAs, and the methodologies used for their detection and quantification. We also discuss possible functions of circulating microRNAs and their potential as non-invasive biomarkers.
microRNAs 对基因表达的调控影响着许多细胞过程，并与许多（病理）生理状态的控制有关。最近，microRNAs 已在血清和血浆中被检测到，循环 microRNA 谱现已与多种不同的肿瘤类型、中风和心脏病等疾病以及妊娠等生理状态改变相关联。在这里，我们回顾了循环 microRNAs 的疾病特异性谱，以及用于检测和定量它们的方法学。我们还讨论了循环 microRNAs 的可能功能及其作为非侵入性生物标志物的潜力。
