氧化平衡评分与前列腺癌风险：病例-队列研究结果。

Oxidative balance score and risk of prostate cancer: results from a case-cohort study.

机构信息

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, United States.

出版信息

Cancer Epidemiol. 2011 Aug;35(4):353-61. doi: 10.1016/j.canep.2010.11.002. Epub 2010 Dec 9.

DOI:10.1016/j.canep.2010.11.002

PMID:21145797

Abstract

BACKGROUND

Prostate cancer is a disease with a complex etiology. Oxidative stress has been implicated in its pathogenesis; however, few prospective studies have investigated the association between an oxidative stress/balance score and risk of prostate cancer.

METHODS

We investigated associations between an oxidative balance score, calculated as the summation of individual scores obtained from five pro-oxidative and eight anti-oxidative exposures, as well as each individual constituent of the score and risks of prostate cancer overall, and by clinical characteristics, in a case-cohort study (661 cases and 1864 subcohort) nested within the Canadian Study of Diet, Lifestyle, and Health cohort. Men in the lowest quintiles of each pro-oxidant exposure received a score of four (the highest score), while those in the highest quintile received a score of zero (the lowest score). In contrast, scoring for all anti-oxidants was performed in the opposite way. Total oxidative balance score was calculated by summating all individual scores of pro- and anti-oxidative variables, with higher values indicating a higher antioxidant status.

RESULTS

The average oxidative balance score was similar between prostate cancer cases and men in the subcohort: 25.2 and 25.3, respectively. There was no association between oxidative balance score and overall risk of prostate cancer with hazard ratios (HRs) of 1.00, 1.02, 1.03, 0.97 and 1.01 for increasing quintiles of the score (p-trend=0.71). There were also no associations for non-advanced or advanced disease, or when analysis was restricted to incident cases that arose after two years of follow-up (n=508). In general constituents of the score were not associated with prostate cancer, except for red meat intake (HR=1.44; 95%CI 1.06-1.95 comparing Q5 vs. Q1) and lycopene (HRs of 0.7-0.8 for increasing quintiles).

CONCLUSION

Our findings do not support an association between oxidative balance score and risks of overall prostate cancer or advanced disease.

摘要

背景

前列腺癌是一种病因复杂的疾病。氧化应激与前列腺癌的发病机制有关；然而，很少有前瞻性研究调查氧化应激/平衡评分与前列腺癌风险之间的关系。

方法

我们在加拿大饮食、生活方式和健康队列研究中进行了一项病例-队列研究（661 例病例和 1864 例亚队列），研究了氧化平衡评分与前列腺癌总体风险以及按临床特征分层的风险之间的关系，该评分是通过将五个促氧化剂和八个抗氧化剂暴露的个体得分相加而得出。每个促氧化剂暴露最低五分位的男性得分为 4 分（最高分），而最高五分位的男性得分为 0 分（最低分）。相比之下，所有抗氧化剂的评分则相反。通过将所有促氧化剂和抗氧化剂的个体得分相加，计算出总氧化平衡评分，得分越高表明抗氧化状态越高。

结果

前列腺癌病例和亚队列男性的平均氧化平衡评分相似：分别为 25.2 和 25.3。氧化平衡评分与前列腺癌总体风险之间没有关联，五分位递增的风险比（HRs）分别为 1.00、1.02、1.03、0.97 和 1.01（趋势检验 p=0.71）。对于非进展性或进展性疾病，或当分析仅限于随访两年后出现的新发病例（n=508）时，也没有相关性。总体评分的组成部分与前列腺癌无关，除了红肉摄入量（五分位 Q5 与 Q1 相比，HR=1.44；95%CI 1.06-1.95）和番茄红素（五分位递增的 HR 为 0.7-0.8）。