联合抗氧化剂和促氧化剂暴露与总体和晚期前列腺癌风险的衡量。
Measures of combined antioxidant and pro-oxidant exposures and risk of overall and advanced stage prostate cancer.
机构信息
Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, The Netherlands.
出版信息
Ann Epidemiol. 2012 Nov;22(11):814-20. doi: 10.1016/j.annepidem.2012.07.010. Epub 2012 Sep 15.
PURPOSE
Oxidative stress is possibly related to prostate carcinogenesis. We constructed a dietary antioxidant score, which is a measure of combined antioxidant exposures, and an oxidative balance score (OBS), which is a measure of combined antioxidant and pro-oxidant exposures. We hypothesized that both scores are inversely associated with the risk of prostate cancer (PCa).
METHODS
We conducted a case-cohort study among 58,279 men in the Netherlands Cohort Study. Cohort members completed a baseline questionnaire. From 1986 to 2003, 3451 patients with PCa were identified including 1196 advanced cancers (stage III/IV). The antioxidant score and the OBS were created by summing quartile and category scores of individual score constituents, which had an equal weight. Pro-oxidants were scored in the opposite way to antioxidants.
RESULTS
Both the antioxidant score and OBS were not associated with risk of overall PCa or PCa subgroups on the basis of disease stage. Most score constituents were not associated with the risk of PCa. Total catechin intake was associated with a decreased risk of stage IV PCa (greatest vs. lowest quartile: hazard ratio, 0.76; 95% confidence interval, 0.59-0.98).
CONCLUSIONS
The antioxidant score and OBS were not associated with risk of overall and advanced-stage PCa.
目的
氧化应激可能与前列腺癌的发生有关。我们构建了一个饮食抗氧化剂评分，这是一种衡量综合抗氧化剂暴露的方法，以及一个氧化平衡评分（OBS），这是一种衡量综合抗氧化剂和促氧化剂暴露的方法。我们假设这两个评分都与前列腺癌（PCa）的风险呈负相关。
方法
我们在荷兰队列研究中进行了一项病例-对照研究。队列成员完成了基线问卷调查。从 1986 年到 2003 年，共发现 3451 名 PCa 患者，其中包括 1196 名晚期癌症（III/IV 期）患者。抗氧化剂评分和 OBS 是通过将个体评分成分的四分位和类别评分相加创建的，每个成分的权重相等。促氧化剂的评分方式与抗氧化剂相反。
结果
基于疾病阶段，抗氧化剂评分和 OBS 均与总体 PCa 或 PCa 亚组的风险无关。大多数评分成分与 PCa 风险无关。总儿茶素摄入量与 IV 期 PCa 风险降低相关（最高与最低四分位比：危险比，0.76；95%置信区间，0.59-0.98）。
结论
抗氧化剂评分和 OBS 与总体和晚期 PCa 的风险无关。
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