p53 密码子 72 多态性在超重人群 2 型糖尿病易感性中的作用？心血管疾病患者的研究。
Is there a role of p53 codon 72 polymorphism in the susceptibility to type 2 diabetes in overweight subjects? A study in patients with cardiovascular diseases.
机构信息
Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
出版信息
Diabetes Res Clin Pract. 2011 Mar;91(3):e64-7. doi: 10.1016/j.diabres.2010.11.031. Epub 2010 Dec 13.
Two hundred and eighty six subjects with cardiovascular diseases and 147 healthy newborns were studied. P53 codon 72 polymorphism was determined by DNA analysis. The association between BMI and diabetes depends on p53 polymorphism: Odds Ratio shows a high significant association between BMI and diabetes in *Arg/*Arg subjects (p=0.00001). No significant association is observed in *Pro allele carriers (p=0.203).
研究了 286 名心血管疾病患者和 147 名健康新生儿。通过 DNA 分析确定 P53 密码子 72 多态性。BMI 和糖尿病之间的关联取决于 p53 多态性：在*Arg/Arg 受试者中，比值比显示 BMI 和糖尿病之间存在高度显著的关联（p=0.00001）。在Pro 等位基因携带者中未观察到显著关联（p=0.203）。
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