The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):32-42. doi: 10.1016/j.bbcan.2018.06.001. Epub 2018 Jun 5.
p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.
p53 是一种重要的肿瘤抑制基因，p53 的缺失导致了大多数人类癌症的发生。然而，p53 在应激信号下的激活为其在健康和疾病的多个方面发挥作用奠定了基础。p53 调节代谢的活性可以在维持体内平衡和保护细胞免受损伤方面发挥作用，从而预防疾病的发生。相比之下，p53 的缺失或过度激活均可导致多种代谢疾病，包括衰老、肥胖和糖尿病。
