TP53 rs1625895 多态性与伊朗老年人肌少症性肥胖风险的关联：一项病例对照研究。
The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study.
机构信息
Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
BMC Musculoskelet Disord. 2021 May 13;22(1):438. doi: 10.1186/s12891-021-04314-5.
BACKGROUND
Aging and obesity are the two major global health concerns. Sarcopenia, an age-linked disease, wherein a progressive loss of muscle volume, muscle strength, and physical activity occurs. In this study we evaluated the association of TP53 rs1625895 polymorphism with the susceptibility to sarcopenic obesity in Iranian old-age subjects.
METHODS
Total of 176 old individuals (45 sarcopenic and 131 healthy) were recruited in this research and genotyped by PCR-RFLP. BMI, Skeletal Muscle Mass Index, body composition, Handgrip Strength, Gait Speed (GS), and biochemical parameters were measured. Chi-square test was done for genotypes and alleles frequency. Linear regression was applied to find the correlation between TP53 rs1625895 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 rs1625895 and the risk of sarcopenia and sarcopenic obesity was investigated by logistic regression.
RESULTS
G allele was significantly higher in sarcopenic obesity group [P = 0.037, OR (CI 95%) = 1.9 (1.03-3.5)] compared to A allele. BMI (P = 0.049) and LDL (P = 0.04) were significantly differed between genotypes when GG was compared to AA/AG genotype. The results revealed when GG genotype compared to AA/AG genotype in adjusted model for age, the risk of sarcopenic obesity [P value = 0.011, OR (CI 95%); 2.72 (1.25-5.91)] increased. Similarly, GG/AG genotype increased the risk of sarcopenic obesity [P value = 0.028, OR (CI 95%); 2.43 (1.10-5.36)] in adjusted model for age compared to AA genotype.
CONCLUSIONS
We suggested that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population.
背景
衰老和肥胖是两个主要的全球健康问题。肌少症是一种与年龄相关的疾病，其特征是肌肉体积、肌肉力量和身体活动的进行性丧失。在这项研究中，我们评估了 TP53 rs1625895 多态性与伊朗老年人群中肌少症性肥胖易感性的关系。
方法
本研究共纳入 176 名老年人（45 名肌少症患者和 131 名健康对照者），采用 PCR-RFLP 法进行基因分型。测量 BMI、骨骼肌质量指数、身体成分、握力、步态速度（GS）和生化参数。采用卡方检验分析基因型和等位基因频率。采用线性回归分析 TP53 rs1625895 多态性与生化和人体测量参数之间的相关性。采用 logistic 回归分析 TP53 rs1625895 与肌少症和肌少症性肥胖风险的相关性。
结果
与 A 等位基因相比，肌少症性肥胖组 G 等位基因明显升高[P=0.037，比值比（95%CI）=1.9（1.03-3.5）]。与 AA/AG 基因型相比，GG 基因型的 BMI（P=0.049）和 LDL（P=0.04）差异有统计学意义。在调整年龄的模型中，与 AA/AG 基因型相比，GG 基因型发生肌少症性肥胖的风险更高[P 值=0.011，比值比（95%CI）为 2.72（1.25-5.91）]。同样，与 AA 基因型相比，在调整年龄的模型中，GG/AG 基因型增加了肌少症性肥胖的风险[P 值=0.028，比值比（95%CI）为 2.43（1.10-5.36）]。
结论
我们认为 TP53 rs1625895 多态性可能增加伊朗人群肌少症性肥胖的风险。
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