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[硬膜外镇痛并非围产期中枢神经系统症状的唯一原因。一例后部可逆性脑病综合征的报告]

[Epidural analgesia is not the only cause of peripartum central neurologic symptoms. Report of one case of posterior reversible encephalopathy syndrome].

作者信息

Etesse B, Letouzey V, Roger C, Lefauconnier A, Ripart J

机构信息

Département d'anesthésie-douleur, GHU Caremeau, place du Pr-Debré, 30029 Nîmes cedex 09, France.

出版信息

Ann Fr Anesth Reanim. 2011 Jan;30(1):57-60. doi: 10.1016/j.annfar.2010.10.003. Epub 2010 Dec 13.

DOI:10.1016/j.annfar.2010.10.003
PMID:21146952
Abstract

A young woman without any significant medical history received an epidural analgesia for labour. She suddenly presented headache, vision loss, nausea and arterial hypertension a few minutes after a 4-ml ropivacaine 0.75% bolus. The catheter was withdrawn and symptoms completely disappeared within 15 minutes. A new epidural catheter was inserted. Thereafter, the patient gave birth to a healthy newborn infant. Half an hour later, while the epidural catheter was still infusing, she presented generalized tonicoclonic seizure. Potential diagnoses were systemic toxicity of local anaesthetics and eclampsia. Accordingly, the patient received intravenous lipid emulsion and magnesium sulphate. There was no biological abnomabilities. A final diagnosis of posterior reversible encephalopathy syndrome was made with MRI showing bilateral hyperintensity areas involving the cortex of the occipital and frontal areas asymmetrically. On the sixth day, after delivery, the patient was discharged seizure-free. Repeated MRI 4 weeks after discharge was unremarkable.

摘要

一名无重大病史的年轻女性在分娩时接受了硬膜外镇痛。在推注4毫升0.75%罗哌卡因几分钟后,她突然出现头痛、视力丧失、恶心和动脉高血压。导管被拔出,症状在15分钟内完全消失。重新插入了一根新的硬膜外导管。此后,患者产下一名健康的新生儿。半小时后,当硬膜外导管仍在输注时,她出现了全身性强直阵挛发作。潜在的诊断是局部麻醉药的全身毒性和子痫。因此,患者接受了静脉注射脂质乳剂和硫酸镁。没有生物学异常。最终诊断为后部可逆性脑病综合征,MRI显示双侧高强度区域不对称地累及枕叶和额叶皮质。产后第六天,患者无癫痫发作出院。出院4周后复查MRI无异常。

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引用本文的文献

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Posterior reversible encephalopathy syndrome during epidural labor analgesia: a case report.硬膜外分娩镇痛期间的后部可逆性脑病综合征:一例报告
JA Clin Rep. 2025 Aug 23;11(1):46. doi: 10.1186/s40981-025-00809-5.
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Postpartum Posterior Reversible Encephalopathy Syndrome (PRES): Three Case Reports and Literature Review.产后后部可逆性脑病综合征(PRES):三例病例报告及文献综述
Case Rep Obstet Gynecol. 2019 Jan 27;2019:9527632. doi: 10.1155/2019/9527632. eCollection 2019.