非酒精性脂肪性肝病与年轻西班牙裔人群的胰岛素抵抗有关。

Nonalcoholic fatty liver disease is associated with insulin resistance in a young Hispanic population.

机构信息

Universidad Militar Nueva Granada, Bogotá, Colombia.

出版信息

Prev Med. 2011 Feb;52(2):174-7. doi: 10.1016/j.ypmed.2010.11.021. Epub 2010 Dec 14.

DOI:10.1016/j.ypmed.2010.11.021

PMID:21147154

Abstract

OBJECTIVE

To investigate whether nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance (IR) in a young Hispanic population.

METHODS

A cross-sectional study was performed in Bogotá, Colombia, during 2006 in 263 males from the Colombian Air Force (age range 29-54 years). Anthropometric measurements and biochemical determinations (glycemia, lipid profile, insulin, and HOMA-IR) were obtained in order to determine the presence of metabolic syndrome (MS) criteria and insulin resistance in this population. In addition, ultrasound studies were performed to evaluate the presence of NAFLD.

RESULTS

NAFLD was detected in 26.6% (n=70) of the subjects. Thirty four individuals had complete MS criteria (48.5%). The presence of NAFLD was associated with higher insulin levels (11.0±5.1 vs. 6.6±3.6, p=0.001), and its prevalence increased from 11% (n=8), to 24% (n=17) to 64% (n=45) from the lowest to the highest HOMA-IR tertile. Body mass index, triglycerides and subcutaneous and visceral fat were found to be independent predictors of NAFLD.

CONCLUSIONS

These results suggest that NAFLD is associated with insulin resistance and extrahepatic adiposity in nondiabetic young Hispanic population.

摘要

目的

研究非酒精性脂肪肝（NAFLD）是否与年轻西班牙裔人群中的胰岛素抵抗（IR）有关。

方法

2006 年在哥伦比亚首都波哥大对来自哥伦比亚空军的 263 名男性（年龄 29-54 岁）进行了一项横断面研究。测量了人体测量学指标和生化指标（血糖、血脂谱、胰岛素和 HOMA-IR），以确定该人群是否存在代谢综合征（MS）标准和胰岛素抵抗。此外，还进行了超声研究以评估是否存在 NAFLD。

结果

26.6%（n=70）的受试者检测到 NAFLD。34 名个体具有完整的 MS 标准（48.5%）。NAFLD 的存在与更高的胰岛素水平相关（11.0±5.1 对 6.6±3.6，p=0.001），其患病率从最低 HOMA-IR 三分位组的 11%（n=8）增加到 24%（n=17），再增加到 64%（n=45）。体重指数、甘油三酯以及皮下和内脏脂肪被认为是 NAFLD 的独立预测因素。