Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Clin Transl Sci. 2013 Feb;6(1):45-9. doi: 10.1111/cts.12007. Epub 2012 Dec 6.
Steatosis is an increasingly common problem worldwide, accompanying increasing obesity. Recently, it has been suggested that oxidative stress plays an important role in development of fatty liver disease. We carried out an epidemiological study to clarify the role of oxidative stress and antioxidative activity in steatosis.
This study was conducted with 184 male workers who had received their annual health checkup. Steatosis was confirmed using ultrasonography. Oxidative stress and antioxidative activity were assessed using the dROM test and the BAP test, respectively.
Steatosis was confirmed in 59 subjects (29.7%) by ultrasonography. There was no significant difference between cases and controls in BAP levels (2229.0 μmol/L vs. 2194.3μmol/L, p = 0.83). The steatosis group showed significantly lower dROM levels than the control group (332.7 U. CARR vs. 316.8 U. CARR, p < 0.05). In addition, we carried out logistic regression analysis to assess the combination between dROM levels and BAP levels. Subjects with high dROM levels and high BAP levels had 74% lower risk for steatosis than subjects with low dROM levels and high BAP levels.
Our results suggested that moderate oxidative stress and high antioxidative activity was associated with decreased steatosis risk in Japanese males.
脂肪变性是一种在全球范围内日益常见的问题，常伴有肥胖症的发生。最近，有研究表明氧化应激在脂肪性肝病的发生发展中起着重要作用。我们进行了一项流行病学研究，旨在阐明氧化应激和抗氧化活性在脂肪变性中的作用。
本研究纳入了 184 名接受年度体检的男性工人。通过超声检查确认脂肪变性。分别使用 dROM 试验和 BAP 试验评估氧化应激和抗氧化活性。
超声检查证实 59 名受试者（29.7%）存在脂肪变性。病例组和对照组的 BAP 水平无显著差异（2229.0μmol/L vs. 2194.3μmol/L，p=0.83）。脂肪变性组的 dROM 水平明显低于对照组（332.7 U.CARR vs. 316.8 U.CARR，p<0.05）。此外，我们进行了逻辑回归分析，以评估 dROM 水平和 BAP 水平的组合。与 dROM 水平低和 BAP 水平高的受试者相比，dROM 水平高和 BAP 水平高的受试者发生脂肪变性的风险降低了 74%。
我们的研究结果表明，日本男性中等程度的氧化应激和高抗氧化活性与较低的脂肪变性风险相关。
