University of Cape Town, Cape Town, South Africa.
Neurosci Biobehav Rev. 2011 Mar;35(4):1075-9. doi: 10.1016/j.neubiorev.2010.11.012. Epub 2010 Dec 13.
Study of the anxiety disorders may be a particularly useful vehicle for demonstrating how foundational sciences (e.g. cognitive-affective neuroscience, evolutionary psychology) can advance psychiatric theory and research. Here we consider important potential advances and remaining future challenges when basic research on threat detection and precautionary responses is used to address the anxiety disorders. We emphasize the potential value of a model of threat detection and precautionary responses that integrates cognitive-affective neuroscience and evolutionary approaches for understanding the anxiety disorders. However, we also suggest that substantial additional work is needed in order to link systematically the psychobiological mechanisms posited by basic work on threat detection and precautionary responses to the complex phenomena seen in the clinic.
焦虑障碍的研究可能是一个特别有用的手段，可以证明基础科学（例如认知情感神经科学、进化心理学）如何促进精神疾病理论和研究的发展。在这里，我们考虑了当基础研究中对威胁检测和预防反应的研究被用于解决焦虑障碍时，可能取得的重要进展和未来仍存在的挑战。我们强调了一种威胁检测和预防反应的模型的潜在价值，该模型整合了认知情感神经科学和进化方法，用于理解焦虑障碍。然而，我们也认为，需要进行大量的额外工作，以便将基础工作中关于威胁检测和预防反应的心理生物学机制与临床上观察到的复杂现象系统地联系起来。
