Tsuji T, Matsumoto Y, Mori K, Ikebe H, Terubayashi H, Akagi Y, Tanimoto T
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1990 Feb;94(2):120-7.
Preventional and reversal effects of a new aldose reductase inhibitor FR74366 on the rat galactose cataract were examined biochemically and light microscopically. A high concentration (0.075%) FR74366 showed sufficient effects both to prevent and reverse cataract, but low concentrations (0.025%) FR74366 was not effective as 0.075% FR74366. These results indicate that FR74366 can be useful drug for cataract.
通过生化和光学显微镜检查，研究了新型醛糖还原酶抑制剂FR74366对大鼠半乳糖性白内障的预防和逆转作用。高浓度（0.075%）的FR74366在预防和逆转白内障方面均显示出足够的效果，但低浓度（0.025%）的FR74366不如0.075%的FR74366有效。这些结果表明，FR74366可能是一种治疗白内障的有效药物。
