Beyer-Mears A, Cruz E, Varagiannis E
Pharmacology. 1985;31(2):88-96. doi: 10.1159/000138103.
Aldose reductase is implicated in the pathogenesis of sugar cataracts; therefore, inhibition of this enzyme subsequent to cataractogenesis may represent a therapeutic approach for the restoration of lens physiology despite the persistence of diabetes or galactosemia. In the present study, the effect of aldose reductase inhibition subsequent to stage-I cataract formation was investigated in the galactose-maintained rat. Our results indicated that despite continuation of galactose feeding the aldose reductase inhibitor, Sorbinil, a spirohydantoin, arrested further progression and promoted a reparative process. Quantitative analysis of scanning electron micrographs indicated that the afflicted lens regions were contained and their cellular components stabilized with regard to fiber hydration and interdigitation. The reparative process involved: decrease in lens dulcitol, gradual recovery of fiber thickness and partial restoration of lens myo-inositol content. At this stage of cataractogenesis, despite continuance of galactose feeding, the effects of Sorbinil treatment were comparable to the reparative process achieved by restoration of a normal diet.
醛糖还原酶与糖性白内障的发病机制有关；因此，尽管糖尿病或半乳糖血症持续存在，但在白内障形成后抑制这种酶可能代表一种恢复晶状体生理功能的治疗方法。在本研究中，在以半乳糖维持的大鼠中研究了I期白内障形成后醛糖还原酶抑制的作用。我们的结果表明，尽管继续喂食半乳糖，但醛糖还原酶抑制剂索比尼尔（一种螺乙内酰脲）可阻止进一步进展并促进修复过程。扫描电子显微镜照片的定量分析表明，受累的晶状体区域得到控制，其细胞成分在纤维水合作用和相互交错方面趋于稳定。修复过程包括：晶状体山梨醇减少、纤维厚度逐渐恢复以及晶状体肌醇含量部分恢复。在白内障形成的这个阶段，尽管继续喂食半乳糖，但索比尼尔治疗的效果与恢复正常饮食所实现的修复过程相当。
