Department of Nursing, Chang Gung Institute of Technology, Taoyuan, Taiwan.
Oral Oncol. 2011 Feb;47(2):131-5. doi: 10.1016/j.oraloncology.2010.11.004. Epub 2010 Dec 13.
Surgical and radiation therapy for oral squamous cell carcinoma (OSCC) may generate orofacial pain. The aims of this study were to (1) characterize the pain experienced by people with orofacial pain, and (2) determine the factors associated with changes in orofacial pain in OSCC patients during the postoperative and post-radiation therapy periods. The study had a prospective longitudinal design with consecutive sampling. Seventy-two eligible patients were recruited from the outpatient department of otolaryngology, head and neck cancer, and radiation therapy of a medical center in northern Taiwan. A set of questionnaires was used for patient assessment, including the University of California San Francisco Oral Cancer Pain Questionnaire, Symptom Severity Scale, Hospital Anxiety and Depression Scale, and Karnofsky's Performance Status Index. Patients were assessed at two time points: 1 month after surgery (T1) and 1 month after completion of radiation treatment (T2). The findings showed that (1) patients reported moderate orofacial pain at both time points; (2) orofacial pain, oral function-related symptoms, and psychological distress were significantly higher at T1 than at T2; and (3) older age, eating difficulty, speech difficulty, and depression were significant predictors of orofacial pain. Oral rehabilitation and relaxation training may reduce orofacial pain in this patient population.
口腔鳞状细胞癌（OSCC）的手术和放射治疗可能会引发口腔颌面部疼痛。本研究的目的是：(1) 描述口腔颌面部疼痛患者的疼痛特征；(2) 确定与 OSCC 患者术后和放疗期间口腔颌面部疼痛变化相关的因素。该研究采用前瞻性纵向设计和连续抽样。共招募了 72 名来自台湾北部一家医学中心耳鼻喉科、头颈部癌症和放疗门诊的合格患者。一套问卷用于评估患者，包括加利福尼亚大学旧金山口腔癌疼痛问卷、症状严重程度量表、医院焦虑和抑郁量表以及卡诺夫斯基表现状态指数。患者在两个时间点进行评估：手术后 1 个月（T1）和放疗结束后 1 个月（T2）。研究结果表明：(1) 患者在两个时间点均报告有中度口腔颌面部疼痛；(2) T1 时的口腔颌面部疼痛、口腔功能相关症状和心理困扰显著高于 T2；(3) 年龄较大、进食困难、言语困难和抑郁是口腔颌面部疼痛的显著预测因素。口腔康复和放松训练可能会减轻该患者群体的口腔颌面部疼痛。
