Department of Psychology, University of Victoria, Victoria, British Columbia, Canada.
Arch Clin Neuropsychol. 2011 Feb;26(1):26-37. doi: 10.1093/arclin/acq093. Epub 2010 Dec 11.
Although older adults with Mild Cognitive Impairment (MCI) show elevated rates of conversion to dementia as a group, heterogeneity of outcomes is common at the individual level. Using data from a prospective 5-year longitudinal investigation of cognitive change in healthy older adults (N = 262, aged 64-92 years), this study addressed limitations in contemporary MCI identification procedures which rely on single occasion assessment ("Single-Assessment [SA] MCI") by evaluating an alternate operational definition of MCI requiring evidence of persistent cognitive impairment over multiple-testing sessions ("Multiple-Assessment [MA] MCI"). As hypothesized, prevalence of SA-MCI exceeded that of MA-MCI. Further, the MA-MCI groups showed lower baseline cognitive and functional performance and steeper cognitive decline compared with Control and SA-MCI group. Results are discussed with reference to retest effects and clinical implications.
虽然轻度认知障碍（MCI）的老年人作为一个群体表现出较高的痴呆转化率，但在个体水平上，结局的异质性很常见。本研究利用一项针对健康老年人认知变化的前瞻性 5 年纵向研究的数据（N=262，年龄 64-92 岁），解决了当代 MCI 识别程序的局限性，这些程序依赖于单次评估（“单次评估 [SA] MCI”），通过评估需要多次测试中持续认知障碍证据的替代 MCI 操作定义（“多次评估 [MA] MCI”）。正如假设的那样，SA-MCI 的患病率超过了 MA-MCI。此外，与对照组和 SA-MCI 组相比，MA-MCI 组的基线认知和功能表现较低，认知下降速度较快。结果与重测效应和临床意义有关。
