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S期检查点介质的多种功能。

Multiple functions of the S-phase checkpoint mediator.

作者信息

Tanaka Katsunori

机构信息

Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan.

出版信息

Biosci Biotechnol Biochem. 2010;74(12):2367-73. doi: 10.1271/bbb.100583. Epub 2010 Dec 7.

DOI:10.1271/bbb.100583
PMID:21150122
Abstract

There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.

摘要

越来越多的证据表明，复制缺陷是细胞中自发基因组不稳定的主要来源，并且S期检查点是抵御这种不稳定的主要防线。S期检查点介导蛋白Mrc1/Claspin通过促进传感激酶对效应激酶的磷酸化来介导对复制应激的检查点反应。在这篇综述中，将讨论S期检查点介导蛋白的多种功能及其调控。

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