真核生物中复制受损 DNA。
Replicating damaged DNA in eukaryotes.
机构信息
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030.
出版信息
Cold Spring Harb Perspect Biol. 2013 Dec 1;5(12):a019836. doi: 10.1101/cshperspect.a019836.
Abstract
DNA damage is one of many possible perturbations that challenge the mechanisms that preserve genetic stability during the copying of the eukaryotic genome in S phase. This short review provides, in the first part, a general introduction to the topic and an overview of checkpoint responses. In the second part, the mechanisms of error-free tolerance in response to fork-arresting DNA damage will be discussed in some detail.
摘要
DNA 损伤是挑战真核生物基因组在 S 期复制过程中保持遗传稳定性的机制的众多可能干扰因素之一。这篇简短的综述首先对该主题进行了一般性介绍，并概述了检验点反应。在第二部分，将详细讨论应对叉子阻断 DNA 损伤的无差错耐受机制。
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