Montreal Behavioural Medicine Centre, Hôpital du Sacré-Cœur de Montréal - Montreal, Quebec, Canada.
Phys Sportsmed. 2010 Dec;38(4):61-6. doi: 10.3810/psm.2010.12.1826.
Exercise-induced asthma (EIA) is common in individuals diagnosed with asthma, with 80% to 90% experiencing asthma symptoms during moderate exercise. Asthma has been linked to obesity such that obesity may be a risk factor for adult-onset asthma. Adults with asthma disclose comorbid obesity as one of the most common barriers to exercise. Physical inactivity has been linked to increases in body mass index (BMI). Few studies have explicitly examined the relationship between BMI and reporting exercise as an asthma trigger. It was hypothesized that individuals with asthma who have an increased BMI will also have increased reports of exercise as an asthma trigger.
In total, 673 adult outpatients with asthma at Hôpital du Sacré-Cœur de Montréal in Montréal, Quebec, Canada underwent a brief sociodemographic and medical history interview. Patients provided information on their height, weight (used to calculate BMI), and triggers that generally provoked an asthma exacerbation (though it should be noted that a formal EIA test was not performed).
When individuals were classified as normal, overweight, or obese, logistic regression analysis revealed that those who were overweight had a 95% increase in the likelihood of reporting exercise-triggered asthma (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.30-2.94) compared with those of normal weight, and this likelihood was more than doubled if the individuals were obese (OR, 2.34; 95% CI, 1.44-3.82). Assessing BMI as a continuous variable revealed that every 1-point increase in BMI was associated with a 9% increase in patients reporting exercise as a trigger (OR, 1.09; 95% CI, 1.04-1.14). All analyses were conducted adjusting for age, sex, asthma severity, and asthma control.
Results suggest that BMI influences the likelihood of reporting exercise as an asthma trigger, such that individuals with higher BMIs report exercise as an asthma trigger more often than those with a lower BMI. Given that the current study is cross-sectional, further prospective research is needed to define the causal pathway of this relationship.
运动性哮喘（EIA）在被诊断患有哮喘的人群中很常见，其中 80%至 90%的患者在中等强度运动时会出现哮喘症状。哮喘与肥胖有关，肥胖可能是成人发病哮喘的一个危险因素。患有哮喘的成年人透露，肥胖是他们进行运动的最大障碍之一。身体活动不足与体重指数（BMI）增加有关。很少有研究明确研究 BMI 与报告运动作为哮喘诱因之间的关系。假设哮喘患者 BMI 增加，报告运动作为哮喘诱因的情况也会增加。
在加拿大魁北克省蒙特利尔的 Sacré-Cœur de Montréal 医院，共有 673 名成年哮喘门诊患者接受了简短的社会人口学和病史访谈。患者提供了身高、体重（用于计算 BMI）和一般引起哮喘加重的诱因信息（尽管应该注意的是，没有进行正式的 EIA 测试）。
当将个体分为正常体重、超重或肥胖时，逻辑回归分析显示，与体重正常者相比，超重者报告运动性哮喘的可能性增加了 95%（比值比 [OR]，1.95；95%置信区间 [CI]，1.30-2.94），如果个体肥胖，这种可能性增加了一倍以上（OR，2.34；95% CI，1.44-3.82）。评估 BMI 作为连续变量表明，BMI 每增加 1 点，患者报告运动作为诱因的可能性增加 9%（OR，1.09；95% CI，1.04-1.14）。所有分析均在调整年龄、性别、哮喘严重程度和哮喘控制的情况下进行。
结果表明，BMI 影响报告运动作为哮喘诱因的可能性，即 BMI 较高的个体比 BMI 较低的个体更频繁地报告运动作为哮喘诱因。鉴于本研究是横断面研究，需要进一步的前瞻性研究来确定这种关系的因果途径。
