Departamento de Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, México.
Ann Nutr Metab. 2010;57(3-4):228-33. doi: 10.1159/000321682. Epub 2010 Dec 8.
Vitamin A deficiency (VAD) is a nutritional problem affecting the health of people in developing countries because VAD compromises innate and adaptive immunity, increasing a person's predisposition toward infectious diseases. In addition, a high prevalence of infectious diseases continues to be a problem in developing countries, including Giardia lamblia. G. lamblia may be related to VAD because of its ability to change the intestinal architecture, thereby compromising the absorption of vitamin A. The aim of this study was to evaluate the effect of giardiasis on serum retinol levels and vitamin A liver stores in school children.
Thirty Giardia-infected school children participated in this study. Vitamin A liver stores were evaluated with the modified relative dose response (MRDR) technique, and antiparasitic treatment was administered. In addition, anthropometric and dietary data were collected.
According to anthropometric indicators (age-appropriate Z scores for weight, height and body mass index) and daily vitamin A intake, the children had a normal nutritional status. Although the mean serum retinol levels did not change significantly after treatment for Giardia (p > 0.05), the MRDR values showed significant improvement (p < 0.002).
Giardiasis not only compromises the vitamin A status through intestinal malabsorption, it also causes profound mobilization of liver retinol stores.
维生素 A 缺乏症（VAD）是一种影响发展中国家人民健康的营养问题，因为 VAD 会损害先天和适应性免疫，增加人们对传染病的易感性。此外，传染病高发仍然是发展中国家的一个问题，包括蓝氏贾第鞭毛虫。由于蓝氏贾第鞭毛虫能够改变肠道结构，从而影响维生素 A 的吸收，因此它可能与 VAD 有关。本研究旨在评估贾第虫病对学龄儿童血清视黄醇水平和维生素 A 肝储存的影响。
30 名感染蓝氏贾第鞭毛虫的学龄儿童参加了这项研究。采用改良相对剂量反应（MRDR）技术评估维生素 A 肝储存量，并进行驱虫治疗。此外，还收集了人体测量学和饮食数据。
根据人体测量学指标（体重、身高和体重指数的年龄适当 Z 分数）和每日维生素 A 摄入量，儿童的营养状况正常。尽管治疗蓝氏贾第鞭毛虫后血清视黄醇水平无显著变化（p>0.05），但 MRDR 值显示出显著改善（p<0.002）。
贾第虫病不仅通过肠道吸收不良损害维生素 A 状态，还会导致肝脏视黄醇储存的大量动员。
