Department of Nucleic Acid Biochemistry, Medical University of Lodz, 92-213 Lodz, Poland.
AllerGen Center of Personalized Medicine, 97-300 Piotrkow Trybunalski, Poland.
Int J Mol Sci. 2024 Aug 7;25(16):8627. doi: 10.3390/ijms25168627.
, the cause of giardiasis, significantly impacts patients with metabolic disorders related to insulin resistance (IR). Both giardiasis and metabolic disorders share elements such as chronic inflammation and intestinal dysbiosis, which substantially affect the metabolic and cytokine profiles of patients. This review discusses the mechanisms of virulence of , its influence on the immune system, and its association with metabolic disorders. The review aims to show how invasion acts on the immune system and the glucose and lipid metabolism. Key findings reveal that infection, by disrupting intestinal permeability, alters microbiota composition and immune responses, potentially impairing metabolic status. Future research should focus on elucidating the specific mechanisms by which influences the metabolism, exploring the long-term consequences of chronic infection, and developing targeted therapeutic strategies that include both parasitic and metabolic aspects. These insights underscore the need for a multidisciplinary approach to the treatment of giardiasis in patients with metabolic disorders.
贾第虫，引起贾第虫病的原因，对与胰岛素抵抗（IR）相关的代谢紊乱患者有重大影响。贾第虫病和代谢紊乱都有共同的特征，如慢性炎症和肠道菌群失调，这极大地影响了患者的代谢和细胞因子谱。这篇综述讨论了贾第虫的毒力机制、对免疫系统的影响及其与代谢紊乱的关系。该综述旨在展示贾第虫感染如何作用于免疫系统和葡萄糖及脂质代谢。研究结果表明，贾第虫感染通过破坏肠道通透性，改变微生物群落组成和免疫反应，可能损害代谢状态。未来的研究应集中阐明贾第虫影响代谢的确切机制，探索慢性感染的长期后果，并制定包括寄生虫和代谢两方面的靶向治疗策略。这些研究结果强调了需要采用多学科方法来治疗代谢紊乱患者的贾第虫病。
