Bhowmick S, Bose R, Pal M, Pal S P
Department of Pharmacy, Jadavpur University, Calcutta, India.
Indian J Exp Biol. 1990 Feb;28(2):190-2.
N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.
N-邻苯二甲酰基γ-氨基丁酸（P. GABA）可抑制白化大鼠在4℃下3小时束缚应激（CRS）诱导的胃溃疡形成。将P. GABA的抗溃疡活性与丙戊酸钠和西咪替丁进行了比较。P. GABA、丙戊酸钠和西咪替丁均呈剂量依赖性地减轻胃溃疡。用GABA拮抗剂——碘化荷包牡丹碱（0.5毫克/千克，腹腔注射）或3-巯基丙酸（2毫克/千克，腹腔注射）预处理可逆转这两种药物（P. GABA和丙戊酸钠）的抗溃疡活性。GABA拮抗剂本身不会在正常大鼠中诱导胃溃疡形成。
