Chatterjee T K, Chakraborty A, Pathak M, Sengupta G C
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Indian J Exp Biol. 1992 Oct;30(10):889-91.
Extract of C. asiatica (Linn.) inhibited significantly gastric ulceration induced by cold and restraint stress (CRS) in Charles-Foster rats, Antiulcer activity of plant extract was compared with famotidine (H2-antagonist) and sodium valproate (anti-epileptic). Plant extract, formotidine and sodium valproate showed a dose dependent reduction of gastric ulceration. Plant extract increased brain GABA level which was also dose dependent. Pretreatment with bicuculline methiodide (specific GABAA-antagonist) at the dose level of 0.5 mg/kg im, reversed the antiulcerogenic activity of both plant extract and sodium valproate. Bicuculline as such did not induce gastric ulceration in normal rat.
积雪草提取物显著抑制了Charles-Foster大鼠因寒冷和束缚应激（CRS）诱导的胃溃疡。将该植物提取物的抗溃疡活性与法莫替丁（H2拮抗剂）和丙戊酸钠（抗癫痫药）进行了比较。植物提取物、法莫替丁和丙戊酸钠均呈现出剂量依赖性的胃溃疡减少。植物提取物使脑内γ-氨基丁酸（GABA）水平升高，且同样呈剂量依赖性。在剂量为0.5mg/kg腹腔注射甲碘化荷包牡丹碱（特异性GABAA拮抗剂）进行预处理后，植物提取物和丙戊酸钠的抗溃疡活性均被逆转。甲碘化荷包牡丹碱本身并不会在正常大鼠中诱发胃溃疡。
