Goel R K, Abbas W R, Maiti R N, Bhattacharya S K
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1996 Aug;34(8):745-9.
To elucidate the involvement of peripheral gamma- aminobutyric acid (GABA) and some GABA-mimetic agents in different models of gastric and duodenal ulcerations in rats and guinea pigs, effects of GABA, baclofen (GABAB agonist), diazepam, gamma-butyrolactone (GABA receptor agonist), sodium valproate, isoniazid (GABA-T inhibitor) and glycine (an inhibitory neurotransmitter), given po or ip were studied. All the drugs significantly reduced the ulcer index, incidence and number of ulcer in various models of gastric ulcers except glycine which failed to protect in reserpine-induced ulcers in rats. None of the drugs, except diazepam, had any protective effect on histamine-induced gastric ulcers in guinea pigs. Similarly, no protection was observed by any drug against cysteamine-induced duodenal ulcers in rats, while sodium valproate, isoniazid and glycine significantly decreased number of ulcers against histamine-induced duodenal ulcer in guinea pigs. The results suggest that GABA and GABA-mimetic agents, and glycine, an inhibitory neurotransmitter, afforded protection against some experimental models of peptic ulcer in rats. The effects appear to be due to their inhibitory effect on mucosal defensive factors.
为阐明外周γ-氨基丁酸（GABA）及一些GABA模拟剂在大鼠和豚鼠不同胃溃疡和十二指肠溃疡模型中的作用，研究了经口或腹腔注射给予GABA、巴氯芬（GABAB激动剂）、地西泮、γ-丁内酯（GABA受体激动剂）、丙戊酸钠、异烟肼（GABA转氨酶抑制剂）和甘氨酸（一种抑制性神经递质）的效果。除甘氨酸对大鼠利血平诱导的溃疡无保护作用外，所有药物均能显著降低各种胃溃疡模型的溃疡指数、溃疡发生率和溃疡数量。除地西泮外，没有一种药物对豚鼠组胺诱导的胃溃疡有保护作用。同样，没有观察到任何药物对大鼠半胱胺诱导的十二指肠溃疡有保护作用，而丙戊酸钠、异烟肼和甘氨酸能显著减少豚鼠组胺诱导的十二指肠溃疡数量。结果表明，GABA、GABA模拟剂以及抑制性神经递质甘氨酸对大鼠某些消化性溃疡实验模型具有保护作用。这些作用似乎归因于它们对黏膜防御因子的抑制作用。
