Suter Melissa, Abramovici Adi, Aagaard-Tillery Kjersti
Baylor College of Medicine, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Pediatr Endocrinol Rev. 2010 Dec;8(2):94-102.
While many fetuses are exposed to tobacco in utero, not all experience adverse outcomes as a result of this exposure. Mechanisms leading to the attenuation of fetal birth weight and adverse pregnancy outcomes are complex. Therefore many studies have begun to focus, not only on the contribution of maternal and fetal genes to phenotypic outcome, but also on epigenetic changes associated with exposure to maternal tobacco smoke. In this review, we detail the epidemiologic evidence associating an adverse pregnancy outcome to maternal tobacco use. We provide a brief summary of studies demonstrating an association between maternal and fetal gene polymorphisms with low birth weight in response to maternal tobacco exposure. We also review the literature showing epigenetic changes in the offspring associated with in utero tobacco exposure. The complex interplay of genomic and epigenomic factors may contribute to specific phenotypic outcomes and can help begin to elucidate the differential susceptibilities to tobacco smoke in utero.
虽然许多胎儿在子宫内接触烟草，但并非所有胎儿都会因此接触而出现不良后果。导致胎儿出生体重减轻和不良妊娠结局的机制很复杂。因此，许多研究不仅开始关注母体和胎儿基因对表型结局的影响，还开始关注与接触母体烟草烟雾相关的表观遗传变化。在这篇综述中，我们详细阐述了将不良妊娠结局与母体吸烟联系起来的流行病学证据。我们简要总结了一些研究，这些研究表明母体和胎儿基因多态性与母体接触烟草后低出生体重之间存在关联。我们还回顾了相关文献，这些文献显示了与子宫内烟草接触相关的后代表观遗传变化。基因组和表观基因组因素的复杂相互作用可能导致特定的表型结局，并有助于开始阐明子宫内对烟草烟雾易感性的差异。
