人类微生物组的发展：为什么妈妈很重要。
The Development of the Human Microbiome: Why Moms Matter.
机构信息
Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine 1 Baylor Plaza, Houston, TX 77030, USA.
Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine 1 Baylor Plaza, Houston, TX 77030, USA.
出版信息
Gastroenterol Clin North Am. 2019 Sep;48(3):357-375. doi: 10.1016/j.gtc.2019.04.004. Epub 2019 Jul 2.
Abstract
The human body is cohabitated with trillions of commensal bacteria that are essential for our health. However, certain bacteria can also cause diseases in the human host. Before the microbiome can be attributed to disease risk and pathogenesis, normal acquisition and development of the microbiome must be understood. Here, we explore the evidence surrounding in utero microbial exposures and the significant of this exposure in the proper development of the fetal and neonatal microbiome. We further explore the development of the fetal and neonatal microbiome and its relationship to preterm birth, feeding practices, and mode of delivery, and maternal diet.
摘要
人体与数万亿种共生细菌共存，这些细菌对我们的健康至关重要。然而，某些细菌也会导致人类宿主患病。在将微生物组归因于疾病风险和发病机制之前，必须了解微生物组的正常获取和发展。在这里，我们探讨了围产期微生物暴露的证据及其在胎儿和新生儿微生物组的正常发育中的重要性。我们还进一步探讨了胎儿和新生儿微生物组的发展及其与早产、喂养方式和分娩方式以及母体饮食的关系。
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