激素难治性（去势抵抗性）前列腺癌中的生长抑素受体亚型。
Somatostatin receptor subtypes in hormone-refractory (castration-resistant) prostatic carcinoma.
机构信息
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona 60126, Italy.
出版信息
Asian J Androl. 2011 Mar;13(2):242-7. doi: 10.1038/aja.2010.100. Epub 2010 Dec 13.
The aim of this study was to examine the tissue expression and localisation of the somatostatin receptors (SSTRs) in hormone-refractory (HR) prostate cancer (PCa). Five SSTRs were evaluated immunohistochemically in 20 radical prostatectomies (RPs) with Gleason score (GS) 3+3=6 PCa, in 20 RPs with GS 4+4=8 and 4+5=9 PCa, and 20 transurethral resection of the prostate specimens with HR PCa. The mean values in the cytoplasm (all five SSTRs were expressed), membrane (only SSTR3 and SSTR4 were expressed) and nuclei (only SSTR4 and SSTR5 were expressed) of the glands in HR PCa were 20-70% lower than in the other two groups, the differences being statistically significant. All five SSTRs were expressed in the smooth muscle and endothelial cells of HR PCa, the mean values being lower than in the other two groups. In conclusion, this study expands our knowledge on the expression and localisation of five SSTRs in the various tissue components in the HR PCa compared with hormone-sensitive PCa.
本研究旨在探讨生长抑素受体（SSTRs）在激素难治性（HR）前列腺癌（PCa）中的组织表达和定位。我们采用免疫组织化学方法检测了 20 例前列腺根治术（RP）中 GS 评分 3+3=6 的 PCa、20 例 GS 评分 4+4=8 和 4+5=9 的 PCa 及 20 例 HR PCa 的经尿道前列腺切除术（TURP）标本中 5 种 SSTR 的表达情况。结果显示，HR PCa 中腺体的细胞质（所有 5 种 SSTR 均有表达）、细胞膜（仅 SSTR3 和 SSTR4 有表达）和核（仅 SSTR4 和 SSTR5 有表达）的平均表达值分别比其他两组低 20-70%，差异具有统计学意义。所有 5 种 SSTR 在 HR PCa 的平滑肌和内皮细胞中均有表达，其平均表达值也低于其他两组。综上所述，与激素敏感性 PCa 相比，本研究扩大了我们对 HR PCa 中 5 种 SSTR 在不同组织成分中的表达和定位的认识。
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