在绒毛膜癌中下调的人类前病毒mRNA编码一种与克虏伯样锌指蛋白相关的蛋白质。
Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel.
作者信息
Kato N, Shimotohno K, VanLeeuwen D, Cohen M
机构信息
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
出版信息
Mol Cell Biol. 1990 Aug;10(8):4401-5. doi: 10.1128/mcb.10.8.4401-4405.1990.
Abstract
RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.
摘要
人类内源性逆转录病毒-R（ERV3）前病毒的RNA转录本在胎盘中大量存在，但在绒毛膜癌中不存在，其3'端含有非前病毒基因组序列。我们在此报告这些基因组序列cDNA克隆的分离情况。这些转录本编码一种与Krüppel相关的锌指蛋白，该蛋白由一个独特的前导区域和超过12个28个氨基酸的指状基序组成。
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