Kariya Y, Kato K, Hayashizaki Y, Himeno S, Tarui S, Matsubara K
Gene. 1987;53(1):1-10. doi: 10.1016/0378-1119(87)90087-4.
Nucleotide sequences of 50 human Alu repeats and their flanking regions are presented together with the consensus sequence based on the literature and our findings. The results indicate the need for some revisions of the Alu consensus sequence published by Deininger et al. (1981). Most nucleotide substitutions among the Alu members are transitions, rather than transversions. The Alu sequence seems to consist of 'conserved' regions and 'variable' regions. The conserved regions consist of a 25-bp region between nt positions 23 and 47 and a 16-bp region between nt positions 245 and 260. The 16-bp region corresponds to the region of 7SL RNA that is claimed to fold and become paired with the internal promoter sequence. Two A-rich regions, one located at the right end of the first monomer and the other at the right end of the second monomer, are variable. No defined property was found with direct repeats flanking the Alu repeats.
本文呈现了50个人类Alu重复序列及其侧翼区域的核苷酸序列，以及基于文献和我们的研究结果得出的共有序列。结果表明，有必要对Deininger等人（1981年）发表的Alu共有序列进行一些修订。Alu成员之间的大多数核苷酸替换是转换，而非颠换。Alu序列似乎由“保守”区域和“可变”区域组成。保守区域包括核苷酸位置23至47之间的一个25 bp区域和核苷酸位置245至260之间的一个16 bp区域。该16 bp区域对应于7SL RNA中据称会折叠并与内部启动子序列配对的区域。两个富含A的区域是可变的，一个位于第一个单体的右端，另一个位于第二个单体的右端。在Alu重复序列侧翼的直接重复序列中未发现明确的特性。
