Cotelli Maria, Manenti Rosa, Rosini Sandra, Calabria Marco, Brambilla Michela, Bisiacchi Patrizia Silvia, Zanetti Orazio, Miniussi Carlo
Istituto Di Ricovero e Cura a Carattere Scientifico, Centro San Giovanni di Dio Fatebenefratelli Brescia, Italy.
Front Aging Neurosci. 2010 Nov 24;2:151. doi: 10.3389/fnagi.2010.00151. eCollection 2010.
Word-retrieval difficulties commonly occur in healthy aging. Recent studies report an improved ability to name pictures after the administration of high-frequency repetitive transcranial magnetic stimulation (rTMS) in healthy younger adults and in patients with neurological disease. The aim of this study was to assess the effect of high-frequency rTMS applied to the dorsolateral prefrontal cortex (DLPFC) on picture naming in healthy older adults. High-frequency rTMS was applied to the left and right DLPFC during object and action naming in 13 healthy older adults. The naming latency for actions was shortened after stimulation of the left and right DLPFC compared to application of the sham stimulation. Stimulation was not observed to have any effect on correctness of naming. Our data demonstrate the involvement of the left and right DLPFC in a sample of healthy aging subjects during an action-naming task. The bilateral involvement of the DLPFC in these participants is discussed together with data on younger adults and on Alzheimer's patients.
词汇检索困难在健康老龄化过程中普遍存在。最近的研究报告称，在健康的年轻人和神经疾病患者中，给予高频重复经颅磁刺激（rTMS）后，图片命名能力有所提高。本研究的目的是评估高频rTMS应用于健康老年人背外侧前额叶皮质（DLPFC）对图片命名的影响。在13名健康老年人进行物体和动作命名时，对其左右DLPFC施加高频rTMS。与假刺激相比，刺激左右DLPFC后动作命名潜伏期缩短。未观察到刺激对命名正确性有任何影响。我们的数据表明，在一项动作命名任务中，左右DLPFC参与了健康老龄化受试者样本。结合关于年轻人和阿尔茨海默病患者的数据，讨论了DLPFC在这些参与者中的双侧参与情况。
