Cotelli Maria, Manenti Rosa, Cappa Stefano F, Geroldi Cristina, Zanetti Orazio, Rossini Paolo M, Miniussi Carlo
Istituto di Recovero e Cura a Carattere Scientifico San Giovanni di Dio Fatebenefratelli, University of Brescia, Brescia, Italy.
Arch Neurol. 2006 Nov;63(11):1602-4. doi: 10.1001/archneur.63.11.1602.
To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD).
Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks.
San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming.
Language ability was assessed by accuracy of verbal response during online rTMS.
Stimulation to the left and right DLPFC improved accuracy in action naming.
These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.
评估重复经颅磁刺激（rTMS）作用于阿尔茨海默病（AD）患者背外侧前额叶皮质（DLPFC）对图片命名的影响。
实验研究。AD患者在图片命名任务期间于真实和对照条件下接受rTMS。
意大利布雷西亚的圣乔瓦尼迪奥-法特贝纳弗拉特利科学研究所。患者 15 例可能患有 AD 的患者。干预 在物体和动作命名期间，对左侧和右侧 DLPFC 施加高频 rTMS。
通过在线 rTMS 期间言语反应的准确性评估语言能力。
对左侧和右侧 DLPFC 的刺激提高了动作命名的准确性。
这些发现表明，rTMS 作用于 DLPFC（在正常对照中可加快动作命名）可改善 AD 患者的表现。虽然这些患者中 rTMS 诱导命名促进的机制尚不清楚，但该程序作为治疗语言功能障碍的新方法可能值得测试。
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