Jiang Liuyan, Marlow Laura A, Cooper Simon J, Roemeling Christina V, Menke David M, Copland John A, Tun Han W
Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA
Int J Clin Exp Pathol. 2010 Oct 8;3(8):763-7.
Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSLforthe CNS and its vasculature.
原发性中枢神经系统淋巴瘤（PCNSL）最常见的是弥漫性大B细胞淋巴瘤（DLBCL），其局限于中枢神经系统（CNS）。我们进行了一项实验，将一名PCNSL患者的淋巴瘤细胞皮下植入无胸腺小鼠体内。通过对大脑的组织学评估显示，淋巴瘤细胞归巢至中枢神经系统，在血管中可见多个大B细胞，符合血管内大B细胞淋巴瘤（IVL）。我们在植入部位或其他位置未发现淋巴瘤的任何证据。这些发现与PCNSL对中枢神经系统及其脉管系统具有高度选择性嗜性一致。
