Rao Nivedita L, Shetty Sukanya, Upadhyaya Krishnaraj, R M Prasad, Lobo Eric C, Kedilaya H P, Prasad Ganesh
Department of Biochemistry, Yenepoya Medical College, Deralakatte, Mangalore 575018, India.
Int J Inflam. 2010 Sep 14;2010:514659. doi: 10.4061/2010/514659.
C-reactive protein (CRP), an acute-phase reactant, has been identified as a saliva-based biomarker of inflammation. The objective of the study was to estimate and compare salivary CRP levels in Hashimoto's thyroiditis (HT) and Subacute thyroiditis (SAT). The study included 30 HT patients who presented with clinical features of hypothyroidism, 15 SAT patients who presented with clinical features of hyperthyroidism, and 20 healthy age- and sex-matched euthyroid controls. CRP levels in saliva were estimated using an Enzyme-Linked Immunosorbent Assay method with enhanced sensitivity. In HT, the mean salivary CRP levels did not differ significantly from controls. SAT patients had significantly elevated salivary CRP levels compared to HT patients and controls. The rise in salivary CRP levels in SAT patients conceivably reflects the presence of an inflammatory process. Saliva CRP levels appear to serve as inflammatory markers in SAT patients and may aid their clinical evaluation.
C反应蛋白（CRP）是一种急性期反应物，已被确定为基于唾液的炎症生物标志物。本研究的目的是评估和比较桥本甲状腺炎（HT）和亚急性甲状腺炎（SAT）患者的唾液CRP水平。该研究纳入了30例表现为甲状腺功能减退临床特征的HT患者、15例表现为甲状腺功能亢进临床特征的SAT患者以及20例年龄和性别匹配的甲状腺功能正常的健康对照。采用灵敏度增强的酶联免疫吸附测定法评估唾液中的CRP水平。在HT患者中，唾液CRP平均水平与对照组无显著差异。与HT患者和对照组相比，SAT患者的唾液CRP水平显著升高。SAT患者唾液CRP水平的升高可能反映了炎症过程的存在。唾液CRP水平似乎可作为SAT患者的炎症标志物，并可能有助于其临床评估。
