Tot Tibor, Pekár Gyula, Hofmeyer Syster, Gere Maria, Tarján Miklós, Hellberg Dan, Lindquist David
Department of Pathology and Clinical Cytology, Central Hospital Falun, S-791 82 Falun, Sweden.
Patholog Res Int. 2010 Nov 3;2011:480960. doi: 10.4061/2011/480960.
We analyzed the subgross distribution of the invasive component in 875 consecutive cases of breast carcinomas using large-format histology sections and compared the immunophenotype (estrogen and progesterone receptor expression, HER2 overexpression and expression of basal-like markers, CK5/6, CK14, and epidermal growth factor receptor) in unifocal, multifocal, and diffuse tumors. Histology grade and lymph node status were also analyzed. Unifocal invasive carcinomas comprised 58.6% (513/875), multifocal invasive carcinomas 36.5% (319/875), and diffuse invasive carcinomas 4.9% (43/875) of the cases. The proportion of lymph node-positive cases was significantly higher in multifocal and diffuse carcinomas compared to unifocal cancers, but no other statistically significant differences could be verified between these tumor categories. Histological multifocality and diffuse distribution of the invasive tumor component seem to be negative morphologic prognostic parameters in breast carcinomas, independent of the molecular phenotype.
我们使用大幅面组织学切片分析了875例连续乳腺癌病例中浸润成分的大体下分布情况，并比较了单灶性、多灶性和弥漫性肿瘤的免疫表型（雌激素和孕激素受体表达、HER2过表达以及基底样标志物CK5/6、CK14和表皮生长因子受体的表达）。还分析了组织学分级和淋巴结状态。单灶性浸润性癌占病例的58.6%（513/875），多灶性浸润性癌占36.5%（319/875），弥漫性浸润性癌占4.9%（43/875）。与单灶性癌相比，多灶性和弥漫性癌中淋巴结阳性病例的比例显著更高，但在这些肿瘤类别之间未发现其他统计学上的显著差异。浸润性肿瘤成分的组织学多灶性和弥漫性分布似乎是乳腺癌的阴性形态学预后参数，与分子表型无关。
