Moinfar Farid
Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Graz, Austria.
Pathobiology. 2008;75(2):119-31. doi: 10.1159/000123850. Epub 2008 Jun 10.
This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results and statistical analysis. The review concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers, but show significant variations in their phenotypes, grades, immunoprofiles and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Well-designed studies with comparison of low-grade nonbasal versus low-grade basal and high-grade nonbasal versus high-grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathological entity.
本综述涉及使用cDNA微阵列和免疫组织化学来鉴定一种称为基底样癌的乳腺癌亚型的研究。对关键的乳腺癌研究进行了批判性讨论，以突出队列选择、定义、结果解释和统计分析中的方法学问题。综述得出结论，基底样癌并不代表单一的、生物学上统一的乳腺癌群体，而是在其表型、分级、免疫特征和临床行为上表现出显著差异，正如在上皮/腔面来源的乳腺癌中观察到的广泛亚型和行为一样。在确信该亚型代表一个独特的临床病理实体之前，有必要进行精心设计的研究，比较低级别非基底样癌与低级别基底样癌以及高级别非基底样癌与高级别基底样癌。
