中国汉族人群中白细胞介素23受体（IL23R）多态性与富克斯综合征的关系
Polymorphisms of IL23R and Fuchs' syndrome in a Chinese Han population.
作者信息
Zhou Hongyan, Jiang Zhengxuan, Yang Peizeng, Hou Shengping, Li Fuzhen, Shu Qinmeng, Chen Yuanyuan, Chen Feilan
机构信息
Zhongshan Ophthalmic Center of Sun Yat-sen University, Guangzhou, PR China.
出版信息
Mol Vis. 2010 Dec 5;16:2585-9.
PURPOSE
The aim of the study was to investigate the association of polymorphisms of the interleukin-23 receptor (IL23R) gene with Fuchs' syndrome in a Chinese Han population.
METHODS
Three single-nucleotide polymorphisms (SNPs), rs7517847, rs11209032 and rs17375018 of IL23R were genotyped in 138 Chinese Han patients with Fuchs' syndrome and 407 healthy controls by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed by χ(2) analysis.
RESULTS
All genotype and allele distributions in patients with Fuchs' syndrome and healthy controls were in Hardy-Weinberg equilibrium. The frequency of the rs11209032 AA genotype was significantly increased in patients with Fuchs' syndrome as compared to controls (corrected p [pc]=0.036, OR 1.86, 95%CI 1.21 to 2.86). There were no statistically significant differences between patients and healthy controls concerning the other two tested SNPs (rs17375018 and rs7517847). The haplotypes of the tested SNPs were not different between patients and controls. Additionally, analysis according to gender did not show any influence of sex on the association of IL23R with Fuchs' syndrome.
CONCLUSIONS
Our results suggested that the rs11209032 AA genotype of the IL23R gene may predispose for Fuchs' syndrome in Chinese patients.
目的
本研究旨在探讨白细胞介素-23受体（IL23R）基因多态性与中国汉族人群中富克斯综合征的相关性。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，对138例中国汉族富克斯综合征患者和407例健康对照者的IL23R基因的3个单核苷酸多态性（SNP），即rs7517847、rs11209032和rs17375018进行基因分型。采用χ(2)分析对数据进行分析。
结果
富克斯综合征患者和健康对照者的所有基因型和等位基因分布均符合哈迪-温伯格平衡。与对照组相比，富克斯综合征患者中rs11209032 AA基因型的频率显著增加（校正P值[pc]=0.036，比值比1.86，95%置信区间1.21至2.86）。在另外两个检测的SNP（rs17375018和rs7517847）方面，患者与健康对照者之间无统计学显著差异。患者和对照组之间检测的SNP单倍型无差异。此外，按性别分析未显示性别对IL23R与富克斯综合征相关性有任何影响。
结论
我们的结果表明，IL23R基因的rs11209032 AA基因型可能使中国患者易患富克斯综合征。
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