汉族富克斯葡萄膜炎综合征患者的CD40基因多态性
CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome.
作者信息
Chen Feilan, Hou Shengping, Jiang Zhengxuan, Li Fuzhen, Chen Yuanyuan, Kijlstra Aize, Yang Peizeng
机构信息
The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, P.R. China.
出版信息
Mol Vis. 2011;17:2469-72. Epub 2011 Sep 23.
PURPOSE
Polymorphisms of the cluster of differentiation 40 (CD40) gene have recently been identified to be associated with the risk to several immune diseases. The aim of this study was to determine the potential association of CD40 polymorphisms with Fuch uveitis syndrome (FUS).
METHODS
A total of 131 Han Chinese patients with FUS and 402 healthy controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype counts in patients and controls were analyzed by the χ(2) test.
RESULTS
All genotypic and allelic frequencies of the tested two CD40 polymorphisms were in Hardy-Weinberg equilibrium. The genotypic and allelic frequencies of rs4810485 and rs1883832 were not different between patients with FUS and controls. No influence of sex could be found following stratification analysis according to gender.
CONCLUSIONS
Our results suggest that the two investigated single-nucleotide polymorphisms (SNPs), rs4810485 and rs1883832, in CD40 are not associated with FUS in the Han Chinese population.
目的
最近已确定分化簇40（CD40）基因的多态性与几种免疫疾病的风险相关。本研究的目的是确定CD40多态性与富克斯葡萄膜炎综合征（FUS）之间的潜在关联。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对131例汉族FUS患者和402例健康对照进行基因分型。通过χ²检验分析患者和对照中的基因型计数。
结果
所检测的两种CD40多态性的所有基因型和等位基因频率均处于哈迪-温伯格平衡。FUS患者和对照之间rs4810485和rs1883832的基因型和等位基因频率没有差异。根据性别进行分层分析后未发现性别影响。
结论
我们的结果表明，CD40中所研究的两个单核苷酸多态性（SNP），即rs4810485和rs1883832，与汉族人群中的FUS无关。
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