Department of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Stem Cells Int. 2010 Dec 1;2010:532704. doi: 10.4061/2010/532704.
Increasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal artificial dermis impregnated and sprayed with local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Autologous adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and tested for Patients who were uneventfully healed with minimal donor-site morbidity, which lasts more than 1.5 years.
人们越来越关注慢性辐射损伤，应该对其进行适当的治疗，以改善伤口管理和提高生活质量。最近，应该尝试采用再生外科方法，使用未培养的自体脂肪来源干细胞 (ADSCs)，将临时人工真皮浸渍并喷涂局部血管生成因子，如碱性成纤维细胞生长因子，然后进行二次重建，可以作为划定和减少供区发病率的候选方法。将自体脂肪来源干细胞、碱性成纤维细胞生长因子的血管生成和有丝分裂因子以及人工真皮应用于切除的放射性皮肤缺损处，并对患者进行了测试，结果显示所有患者均无并发症愈合，供区发病率低，且持续时间超过 1.5 年。
