Todo S, Podesta L, Ueda Y, Imventarza O, Casavilla A, Oks A, Okuda K, Nalesnik M, Venkataramanan R, Starzl T E
Departments of Surgery and Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Clin Transplant. 1989 Oct;3(5):253-259.
The efficacy of the University of Wisconsin (UW) solution was compared with conventional Euro-Collins solution, as well as with 3 variants of a silica gel solution developed at the University of Minnesota (UM). Protection of the liver grafts with UW was superior after 24 hour preservation, although the results were inferior to those with immediate transplantation, as judged by animal survival, liver function tests, coagulation, and histopathologic parameters. The UM-III solution allowed similar animal survival as with the UW solution. Lactobionate and raffinose that are contained in both the UW and UM-III solutions were thought to be essential constituents for long-term preservation of liver grafts. The study not only establishes, under controlled circumstances, the superiority of the UW solution, but it also provides insight about the reasons for its effectiveness as well as a caution against its over exploitation.
将威斯康星大学（UW）溶液的功效与传统的欧洲柯林斯溶液以及明尼苏达大学（UM）研发的硅胶溶液的3种变体进行了比较。根据动物存活率、肝功能测试、凝血和组织病理学参数判断，UW溶液在肝脏移植保存24小时后对肝脏移植物的保护效果更佳，尽管结果不如即刻移植。UM-III溶液的动物存活率与UW溶液相似。UW溶液和UM-III溶液中含有的乳糖酸和棉子糖被认为是肝脏移植物长期保存的必需成分。该研究不仅在可控条件下证实了UW溶液的优越性，还深入了解了其有效性的原因，并提醒人们不要过度使用。
