131例非配对尸体肾移植中环孢素-类固醇疗法的长期结果
Long-term results of cyclosporine-steroid therapy in 131 non-matched cadaveric renal transplants.
作者信息
Gordon Robert D, Starzl Thomas E, Hakala Thomas R, Taylor Rodney J, Schroter Gerhard P J, Rosenthal J Thomas, Well Richard, Iwatsuki Shunzaburo, Carpenter Barbara J
机构信息
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Veterans Administration Medical Center, Pittsburgh, PA, and the University of Colorado Health Sciences Center, Denver, CO U.S.A.
出版信息
Clin Transplant. 1987;1(1):44-48.
One-hundred-and-twenty-eight recipients of 131 consecutive, non-matched cadaver renal allografts were treated with cyclosporine and steroids. They have been followed for 4 to 6 yr. Cumulative patient survival at 1-yr was 92.2% and at 6yr it is 77.8%. Cumulative graft survival at 1-yr was 79.4% and at 6 yr it is 50.0%. After the high-risk 1st yr, the rate of graft loss was even and similar to that reported after the 1st yr for grafts treated with azathioprine and steroids. This indicates that cyclosporine nephrotoxicity has not had an obvious adverse effect on the survival of chronically functioning grafts. The results were better with primary grafting versus retransplantation, but were not significantly influenced by age, diabetes mellitus, or a delayed switch in patients from cyclosporine to azathioprine. We have concluded that cyclosporine-steroid therapy is safe and effective for long-term use after cadaveric renal transplantation.
131例连续非配对尸体肾移植的128例受者接受了环孢素和类固醇治疗。他们已被随访4至6年。1年时的累积患者生存率为92.2%，6年时为77.8%。1年时的累积移植物生存率为79.4%，6年时为50.0%。在高风险的第1年后，移植物丢失率平稳，与用硫唑嘌呤和类固醇治疗的移植物在第1年后报告的情况相似。这表明环孢素肾毒性对长期功能良好的移植物的存活没有明显的不利影响。初次移植的结果优于再次移植，但不受年龄、糖尿病或患者从环孢素改为硫唑嘌呤的时间延迟的显著影响。我们得出结论，环孢素-类固醇疗法在尸体肾移植后长期使用是安全有效的。
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