Virgolini I, Fitscha P, Linet O I, O'Grady J, Sinzinger H
2nd Department of Internal Medicine, Policlinic, Vienna, Austria.
Prostaglandins. 1990 Jun;39(6):657-64. doi: 10.1016/0090-6980(90)90025-q.
108 patients with ischemic peripheral vascular disease were randomly allocated to receive infusion of either PGI2 (6 ng/kg/min over 8 hours daily for 5 consecutive days) or placebo in a double-blind manner. All patients had Stage II disease (Fontaine classification). One month after infusion the absolute and relative walking times were significantly (p less than 0.05) longer in the PGI2- than in the placebo-treated group. Patients were further classified as treatment responders or non-responders on the basis of increase of absolute and relative walking times. After one month 44% (24 out of 54) of the PGI2- and 15% (8 out of 54) of the placebo-treated patients were positive treatment-responders (p less than 0.01).
108例缺血性周围血管疾病患者被随机分配，以双盲方式接受前列环素（PGI2）输注（每天8小时，6 ng/kg/分钟，连续5天）或安慰剂。所有患者均为II期疾病（Fontaine分级）。输注1个月后，PGI2治疗组的绝对和相对步行时间显著长于安慰剂治疗组（p<0.05）。根据绝对和相对步行时间的增加，将患者进一步分为治疗反应者或无反应者。1个月后，PGI2治疗组44%（54例中的24例）和安慰剂治疗组15%（54例中的8例）为阳性治疗反应者（p<0.01）。
