Hay C R, Waller P C, Carter C, Cameron H A, Parnell L, Ramsay L E, Preston F E, Greaves M
Thromb Res. 1987 Apr 15;46(2):317-24. doi: 10.1016/0049-3848(87)90293-3.
24 hour infusion of iloprost was compared with placebo infusion in 19 patients with stable intermittent claudication using a double blind, balanced crossover design. Despite significant inhibition of platelet aggregation to ADP and collagen (p less than 0.001) and the typical cardiovascular and gastrointestinal side effects, there was no significant effect on treadmill exercise times at any time up to 6 weeks after infusion. The 95% confidence limits indicated that an improvement of more than 25% was unlikely to occur. No significant changes in B thromboglobulin, platelet aggregate ratio, bleeding time, whole blood viscosity and euglobulin clot lysis time were demonstrated.
采用双盲、平衡交叉设计，对19例稳定型间歇性跛行患者进行了伊洛前列素24小时输注与安慰剂输注的比较。尽管对二磷酸腺苷（ADP）和胶原诱导的血小板聚集有显著抑制作用（p<0.001），且出现了典型的心血管和胃肠道副作用，但在输注后长达6周的任何时间，对跑步机运动时间均无显著影响。95%置信区间表明，改善超过25%的情况不太可能发生。β-血小板球蛋白、血小板聚集率、出血时间、全血粘度和优球蛋白凝块溶解时间均无显著变化。
