Potter Michelle C, Yuan Chunyan, Ottenritter Conwell, Mughal Mohamed, van Praag Henriette
NIA; NIA/NIH, Baltimore,Maryland; National Institute of Aging, National Institute of Health and Neuroplasticity and Behavior Unit NIA/NIH.
PLoS Curr. 2010 Dec 7;2:RRN1201. doi: 10.1371/currents.RRN1201.
Exercise benefits both general health and brain function in rodents and humans. However, it is less clear whether physical activity prevents or ameliorates neurodegenerative diseases. The aim of the present study was to determine whether voluntary wheel running can delay the onset or reduce the severity of Huntington's disease (HD) in a mouse model. To investigate whether running may delay HD symptoms lifespan, disease onset, locomotor activity, glucose levels, weight, striatal volume, inclusions, cognition and hippocampal neurogenesis were studied in male N171-82Q transgenic HD mice. Running started in pre-symptomatic (44±1 days old) male HD mice, did not improve function and appeared to accelerate disease onset. In particular, HD runners had an earlier onset of disease symptoms (shaking, hunched back and poor grooming), reduced striatal volume and impaired motor behavior, including a shorter latency to fall from the rotarod compared to sedentary controls. Furthermore, weight loss, reduced lifespan, hyperglycemia, Morris water maze learning deficits, diminished hippocampal neurogenesis, deficits in immature neuronal morphology, intranuclear inclusions and decreased dentate gyrus volume were refractory to physical activity. Taken together our research indicates that exercise is not beneficial, and may be detrimental to a vulnerable nervous system.
运动对啮齿动物和人类的总体健康及大脑功能均有益处。然而，体育活动是否能预防或改善神经退行性疾病，目前尚不清楚。本研究的目的是确定在小鼠模型中，自愿进行轮转跑步是否能延缓亨廷顿舞蹈病（HD）的发病或减轻其严重程度。为了研究跑步是否可能延缓HD症状、寿命、疾病发作、运动活动、血糖水平、体重、纹状体体积、包涵体、认知和海马神经发生，对雄性N171 - 82Q转基因HD小鼠进行了研究。跑步在症状前期（44±1日龄）的雄性HD小鼠中开始，并未改善功能，反而似乎加速了疾病发作。特别是，HD跑步小鼠出现疾病症状（颤抖、驼背和梳理毛发不佳）的时间更早，纹状体体积减小，运动行为受损，包括与久坐不动的对照组相比，从转棒上掉落的潜伏期更短。此外，体重减轻、寿命缩短、高血糖、莫里斯水迷宫学习缺陷、海马神经发生减少、未成熟神经元形态缺陷、核内包涵体以及齿状回体积减小对体育活动均无反应。综合来看，我们的研究表明运动并无益处，且可能对脆弱的神经系统有害。
