Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA.
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2367-72. doi: 10.1073/pnas.0911725107. Epub 2010 Jan 19.
Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves learning, but specific mechanisms of information processing influenced by physical activity are unknown. Here, we report that voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli. Improved spatial pattern separation in adult runners was tightly correlated with increased neurogenesis. In contrast, very aged (22 months old) mice had impaired spatial discrimination and low basal cell genesis that was refractory to running. These findings suggest that the addition of newly born neurons may bolster dentate gyrus-mediated encoding of fine spatial distinctions.
越来越多的证据表明，有规律的运动可以改善大脑健康，促进突触可塑性和海马神经发生。运动可以改善学习，但运动影响信息处理的具体机制尚不清楚。在这里，我们报告说，自愿跑步增强了成年（3 个月大）雄性 C57BL/6 小鼠区分两个相邻相同刺激物位置的能力。成年跑步者的空间模式分离能力提高与神经发生增加密切相关。相比之下，非常年老（22 个月大）的老鼠的空间辨别能力受损，基础细胞生成率低，且对跑步没有反应。这些发现表明，新生神经元的增加可能会增强齿状回介导的精细空间区分的编码。
