Samarasinghe Venura, Madan Vishal, Lear John T
Manchester Royal Infirmary, Central Manchester and Manchester Childrens' Hospital NHS Trust, Oxford Road, Manchester M13 9WL, UK.
J Skin Cancer. 2011;2011:328615. doi: 10.1155/2011/328615. Epub 2010 Oct 24.
Nonmelanoma skin cancers (NMSCs), which include basal and squamous cell cancers are the most common human cancers. BCCs have a relatively low metastatic rate and slow growth and are frequently underreported. Whilst there is a definite role of sunexposure in the pathogenesis of BCC, several additional complex genotypic, phenotypic and environmental factors are contributory. The high prevalence and the frequent occurrence of multiple primary BCC in affected individuals make them an important public health problem. This has led to a substantial increase in search for newer noninvasive treatments for BCC. Surgical excision with predetermined margins remains the mainstay treatment for most BCC. Of the newer non-invasive treatments only photodynamic therapy and topical imiquimod have become established in the treatment of certain BCC subtypes, while the search for other more effective and tissue salvaging therapies continues. This paper focuses on the pathogenesis and management of BCC.
非黑色素瘤皮肤癌（NMSCs），包括基底细胞癌和鳞状细胞癌，是最常见的人类癌症。基底细胞癌转移率相对较低，生长缓慢，且经常报告不足。虽然阳光照射在基底细胞癌的发病机制中具有明确作用，但还有其他一些复杂的基因型、表型和环境因素也起作用。受影响个体中基底细胞癌的高患病率和多发原发性基底细胞癌的频繁发生使其成为一个重要的公共卫生问题。这导致人们大量寻求治疗基底细胞癌的更新型非侵入性治疗方法。采用预定切缘的手术切除仍是大多数基底细胞癌的主要治疗方法。在更新型非侵入性治疗方法中，只有光动力疗法和局部咪喹莫特已确立用于某些基底细胞癌亚型的治疗，而对其他更有效和能保留组织的疗法的探索仍在继续。本文重点关注基底细胞癌的发病机制和治疗。
