Friedman Robert M, Contente Sara
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Hepat Res Treat. 2010;2010:323926. doi: 10.1155/2010/323926. Epub 2010 Sep 6.
Interferons were first described in 1957, but it was not until 34 years after their discovery that sufficient quantities of it were available for treatment of hepatitis C virus (HCV) infections, Clinicians now have an excellent understanding of the basis for the effectiveness of interferon alpha (IFN-α) in the therapy of this disease. Treatment with IFN-α is more efficient when it complemented by the antiviral ribavirin and the IFN-α is conjugated with polyethylene glycol to form peginterferon. In the near future treatment of HCV with IFN-α may involve new anti-HCV agents that are currently under development.
干扰素于1957年首次被描述，但直到其发现34年后，才有足够数量的干扰素可用于治疗丙型肝炎病毒（HCV）感染。临床医生现在对α干扰素（IFN-α）治疗这种疾病的有效性基础有了很好的理解。当与抗病毒药物利巴韦林联合使用且IFN-α与聚乙二醇结合形成聚乙二醇干扰素时，用IFN-α治疗更有效。在不久的将来，用IFN-α治疗HCV可能会涉及目前正在研发的新型抗HCV药物。
