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老年心力衰竭患者对β受体阻滞剂的耐受性差。

Poor tolerance of beta-blockers by elderly patients with heart failure.

机构信息

Department of Cardiology, Okazaki City Hospital, Aichi, Japan.

出版信息

Clin Interv Aging. 2010 Nov 26;5:365-8. doi: 10.2147/CIA.S15158.

DOI:10.2147/CIA.S15158
PMID:21152238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2998243/
Abstract

Despite the well-understood importance of beta-blocker therapy in heart failure, it is sometimes not possible to use beta-blockers in elderly patients due to poor tolerance. In this report, we describe the case of an 83-year-old patient with severe systolic heart failure complicated by aortic valve stenosis and atrial fibrillation. A simple therapeutic approach involving discontinuation of beta-blockers remarkably alleviated the symptoms such as left ventricular ejection fraction, and improved the chest radiography and laboratory findings; further, atrial fibrillation converted to sinus rhythm. It is important to carefully administer beta-blocker therapy to elderly patients with heart failure, especially after considering cardiac output.

摘要

尽管β受体阻滞剂在心衰治疗中的重要性已被充分认识,但由于老年患者耐受性差,有时无法使用β受体阻滞剂。在本报告中,我们描述了一位 83 岁的患者,患有严重的收缩性心力衰竭,合并主动脉瓣狭窄和心房颤动。一种简单的治疗方法,包括停用β受体阻滞剂,显著缓解了左心室射血分数等症状,并改善了胸部 X 线和实验室检查结果;此外,心房颤动转为窦性心律。对于心力衰竭的老年患者,β受体阻滞剂治疗需要谨慎,特别是在考虑心输出量后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/2998243/722a0d34e964/cia-5-365f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/2998243/5446af91d7d9/cia-5-365f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/2998243/722a0d34e964/cia-5-365f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/2998243/5446af91d7d9/cia-5-365f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/2998243/722a0d34e964/cia-5-365f2.jpg

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Eur J Heart Fail. 2009 Aug;11(8):802-5. doi: 10.1093/eurjhf/hfp102.
2
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Am Heart J. 2008 Mar;155(3):455-64. doi: 10.1016/j.ahj.2007.10.041. Epub 2008 Jan 31.
3
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Br J Clin Pharmacol. 2007 Mar;63(3):356-64. doi: 10.1111/j.1365-2125.2006.02769.x. Epub 2006 Sep 12.
4
Risk-treatment mismatch in the pharmacotherapy of heart failure.心力衰竭药物治疗中的风险-治疗不匹配
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