Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark;
Clin Epidemiol. 2010 Oct 27;2:247-50. doi: 10.2147/CLEP.S13815.
The purpose of this study is to validate the diagnosis of spontaneous abortion (SA) recorded in the Danish National Registry of Patients (DNRP).
We randomly selected patients registered in the DNRP with a diagnosis of SA between 1980 and 2008 from hospitals in the county of North Jutland and searched for their discharge records in hospital files. We estimated positive predictive value (PPV) of the DNRP diagnosis and stratified the analysis by period (1980-1994 versus 1995-2008), hospital type (regional versus local), and International Classification of Diseases revisions (ICD-8 versus ICD-10).
We could identify hospital files of 117/174 (67%) sampled registration records. Of those, the diagnosis was confirmed in 114 patients, yielding a PPV of 97.4% (95% confidence interval = 92.7%-99.5%). The PPV did not markedly vary by period, hospital type, or ICD revision. Among the three patients with available data who did not fulfill the criteria for SA, one had an induced abortion and two had threatened abortion but did not miscarry.
Registration of SA in the DNRP accurately reflects the diagnoses recorded in medical charts. The DNRP is a suitable source of data on SAs for epidemiologic research.
本研究旨在验证丹麦国家患者登记处（DNRP）中记录的自然流产（SA）诊断的准确性。
我们从北日德兰郡的医院中随机选择了 1980 年至 2008 年期间在 DNRP 登记为 SA 的患者，并在医院档案中查找他们的出院记录。我们估计了 DNRP 诊断的阳性预测值（PPV），并按时间段（1980-1994 年与 1995-2008 年）、医院类型（区域与地方）和国际疾病分类修订版（ICD-8 与 ICD-10）进行了分层分析。
我们能够识别出 174 个抽样登记记录中的 117 个（67%）医院档案。其中，114 名患者的诊断得到了确认，阳性预测值为 97.4%（95%置信区间=92.7%-99.5%）。阳性预测值在时间段、医院类型或 ICD 修订方面没有明显差异。在有可用数据的三位不符合 SA 标准的患者中，一位进行了人工流产，两位有先兆流产但未流产。
DNRP 中 SA 的登记准确反映了医疗记录中记录的诊断。DNRP 是用于流行病学研究的 SA 数据的合适来源。
